Article
Stage-dependent responses of the developing lung to retinoic acid signaling.
The International journal of developmental biology - 1 Aug 2000
Mollard R, Ghyselinck N B, Wendling O, Chambon P, Mark M
Abstract excerpt
Morphological analysis of vitamin A-deficient rat fetuses and of retinoic acid receptor (RAR and RXR) mutant mice have demonstrated that retinoic acid (RA) is essential for lung development. To gainfurther insight into RA signaling pathways during primary lung budformation and lung branching, we have investigated the effects of RA and of a pan-RAR antagonist in cultures of whole embryos and lung explants....
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