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Article

Enhanced productivity of protease-sensitive heterologous proteins by disruption of multiple protease genes in the fission yeast Schizosaccharomyces pombe.

Applied microbiology and biotechnology - 1 Nov 2006

Idiris Alimjan, Tohda Hideki, Bi Ke-wei, Isoai Atsushi, Kumagai Hiromichi, Giga-Hama Yuko

Abstract excerpt

The creation of protease-deficient mutants to avoid product degradation is one of the current strategies employed to improve productivity and secretion efficiency of heterologous protein expression. We previously constructed a set of single protease-deficient mutants of the fission yeast Schizosaccharomyces pombe by respective disruption of 52 protease genes, and we succeeded in confirming useful disruptants...

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PMID: 16802154
DOI: 10.1007/s00253-006-0489-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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