Article
Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for cyclosporine.
Journal of receptor research - 1 Jan 1991
Ryffel B, Woerly G, Rodriguez C, Foxwell B M
Abstract excerpt
The immunosuppressive agent cyclosporine A (CSA) has been shown to reverse multidrug resistance (MDR) in malignant cells. In the present study, a 3H-cyclosporine diazirine analogue (3H-PL-CS) was used to photolabel viable MDR cells. The 170 kDa membrane P-glycoprotein, which functions as a drug e...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antineoplastic Agents
- Blotting, Western
- Breast Neoplasms
- Cell Line
- Cyclosporins
- Drug Resistance
- Female
- Humans
- Membrane Glycoproteins
- Neoplasm Proteins
- Ovarian Neoplasms
- Phenotype
- Precipitin Tests
- Tumor Cells, Cultured