Article
Cyclosporine induces cancer progression by a cell-autonomous mechanism.
Nature - 11 Feb 1999
Hojo M, Morimoto T, Maluccio M, Asano T, Morimoto K, Lagman M, Shimbo T, Suthanthiran M
Abstract excerpt
Malignancy is a common and dreaded complication following organ transplantation. The high incidence of neoplasm and its aggressive progression, which are associated with immunosuppressive therapy, are thought to be due to the resulting impairment of the organ recipient's immune-surveillance system. Here we report a mechanism for the heightened malignancy that is independent of host immunity. We show that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.