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Article

Interactions of cyclosporin a with breast cancer resistance protein.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2007

Xia Cindy Q, Liu Ning, Miwa Gerald T, Gan Liang-Shang

Abstract excerpt

The objective of this study was to investigate whether cyclosporin A (CsA) is a modulator for breast cancer resistance protein (BCRP). The interactions between CsA and BCRP were evaluated by using both membrane- and cell-based assays. CsA inhibited BCRP or BCRP R482T mutant-associated ATPase with an IC(50) of 26.1 and 7.3 microM (31,388 and 8779 ng/ml), respectively, indicating that CsA is a modulator for BCRP...

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PMID: 17220244
DOI: 10.1124/dmd.106.011866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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