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Article

Identification of a new chondropsin class of antitumor compound that selectively inhibits V-ATPases.

The Journal of biological chemistry - 7 Nov 2003

Bowman Emma Jean, Gustafson Kirk R, Bowman Barry J, Boyd Michael R

Abstract excerpt

We identify a new naturally occurring class of inhibitor of vacuolar H+-ATPases (V-ATPases) isolated from vacuolar membranes of Neurospora crassa and from chromaffin granule membranes of Bos taurus. To date, the new class includes six chondropsins and poecillastrin A, large polyketide-derived macrolide lactams with 33-37 membered rings. In the National Cancer Institute's 60-cell screen the chondropsin class...

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Identifiers

PMID: 12944415
DOI: 10.1074/jbc.M306595200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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