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Article

The binding site of the V-ATPase inhibitor apicularen is in the vicinity of those for bafilomycin and archazolid.

The Journal of biological chemistry - 14 Sept 2012

Osteresch Christin, Bender Tobias, Grond Stephanie, von Zezschwitz Paultheo, Kunze Brigitte, Jansen Rolf, Huss Markus, Wieczorek Helmut

Abstract excerpt

The investigation of V-ATPases as potential therapeutic drug targets and hence of their specific inhibitors is a promising approach in osteoporosis and cancer treatment because the occurrence of these diseases is interrelated to the function of the V-ATPase. Apicularen belongs to the novel inhibitor family of the benzolactone enamides, which are highly potent but feature the unique characteristic of not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22815478
DOI: 10.1074/jbc.M112.372169
PMCID: PMC3442520

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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