NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild-Type Receptors: Identification of Highly Selective Inhibitors That Block the Process.

Abstract excerpt

Cerebral autosomal dominant arteriopathy with subcortical infarctions and leukoencephalopathy (CADASIL) is a monogenic autosomal dominant small vessel disease clinically characterized by a broad spectrum of symptoms including recurrent ischemic strokes, cognitive dysfunction, and premature dementia. It is caused (predominantly) by cysteine-altering mutations in exons encoding the epidermal growth factor-like...

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• CADASIL
• JAG1 gene
• NOTCH3 gene
• HEK293 Cells
• Mutation