Article
The novel Helicobacter pylori CznABC metal efflux pump is required for cadmium, zinc, and nickel resistance, urease modulation, and gastric colonization.
Infection and immunity - 1 Jul 2006
Stähler Frank Nils, Odenbreit Stefan, Haas Rainer, Wilrich Julia, Van Vliet Arnoud H M, Kusters Johannes G, Kist Manfred, Bereswill Stefan
Abstract excerpt
Maintaining metal homeostasis is crucial for the adaptation of Helicobacter pylori to the gastric environment. Iron, copper, and nickel homeostasis has recently been demonstrated to be required for the establishment of H. pylori infection in animal models. Here we demonstrate that the HP0969-0971 gene cluster encoding the Czc-type metal export pump homologs HP0969, HP0970, and the H. pylori-specific protein...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.