Article
Allelic exchange mutagenesis of nixA in Helicobacter pylori results in reduced nickel transport and urease activity.
Infection and immunity - 1 Jul 1996
Bauerfeind P, Garner R M, Mobley L T
Abstract excerpt
Helicobacter pylori, an etiologic agent of gastritis and peptic ulceration in humans, synthesizes urease, a nickel metalloenzyme, as its most abundant protein. NixA, a high-affinity nickel transport protein, allows synthesis of catalytically active urease when coexpressed with H. pylori urease in an Escherichia coli host. To determine whether NixA is essential for the production of active urease in H. pylori,...
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