Article
In vitro analysis of genomic instability triggered by BRCA1 missense mutations.
Human mutation - 1 Jul 2006
Quaresima Barbara, Faniello Maria Concetta, Baudi Francesco, Crugliano Telma, Cuda Giovanni, Costanzo Francesco, Venuta Salvatore
Abstract excerpt
The BRCA1 tumor suppressor gene encodes a phosphoprotein involved in many cellular key functions including DNA repair, transcription regulation, cell-cycle control and apoptosis. Most of these functions are strictly related to the ability of BRCA1 to interact with the other partners of a multimeric complex called BASC. Among these components, an important role is played by the human homolog of the bacterial MutL,...
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