Article
A synergetic effect of BARD1 mutations on tumorigenesis.
Nature communications - 23 Feb 2021
Li Wenjing, Gu Xiaoyang, Liu Chunhong, Shi Yanyan, Wang Pan, Zhang Na, Wu Rui, Leng Liang, Xie Bingteng, Song Chen, Li Mo
Abstract excerpt
To date, a large number of mutations have been screened from breast and ovarian cancer patients. However, most of them are classified into benign or unidentified alterations due to their undetectable phenotypes. Whether and how they could cause tumors remains unknown, and this significantly limits diagnosis and therapy. Here, in a study of a family with hereditary breast and ovarian cancer, we find that two BARD1...
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