Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2006

Matsuzaki Yohei, Xu Yan, Ikegami Machiko, Besnard Valérie, Park Kwon-Sik, Hull William M, Wert Susan E, Whitsett Jeffrey A

Abstract excerpt

The role of Stat3 in the maintenance of pulmonary homeostasis following adenoviral-mediated lung injury was assessed in vivo. Stat3 was selectively deleted from bronchiolar and alveolar epithelial cells in Stat3(DeltaDelta) mice. Although lung histology and function were unaltered by deletion of Stat3 in vivo, Stat3(DeltaDelta) mice were highly susceptible to lung injury caused by intratracheal administration of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae Infections
Share to bcl-X Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caspase 3

Share to Caspases

Share to Cytoprotection

Share to Pulmonary Alveoli

Share to Respiratory Mucosa

Share to STAT3 Transcription Factor

Source

Identifiers

PMID: 16785550
DOI: 10.4049/jimmunol.177.1.527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection.PMID 16785550Read ↗

STAT3 Negatively Regulates Type I IFN-Mediated Antiviral ResponseSemantic proximity Read ↗

Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cellsSemantic proximity Read ↗

A novel oncolytic adenovirus selectively silences the expression of tumor-associated STAT3 and exhibits potent antitumoral activity.Semantic proximity Read ↗

STAT3 deletion sensitizes cells to oxidative stress.Semantic proximity Read ↗

STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral ControlSemantic proximity Read ↗

Differential roles of STAT3 in the initiation and growth of lung cancer.Semantic proximity Read ↗

The SH Integral Membrane Protein of the Paramyxovirus Simian Virus 5 Is Required To Block Apoptosis in MDBK CellsSemantic proximity Read ↗

STAT3 regulates proliferation and survival of CD8+ T cells: enhances effector responses to HSV-1 infection, and inhibits IL-10+ regulatory CD8+ T cells in autoimmune uveitis.Semantic proximity Read ↗

Roles of Vaccinia Virus Genes E3L and K3L and Host Genes PKR and RNase L during Intratracheal Infection of C57BL/6 MiceSemantic proximity Read ↗

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease.Semantic proximity Read ↗

The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins.Semantic proximity Read ↗

Ubiquitination of the Transcription Factor IRF-3 Activates RIPA, the Apoptotic Pathway that Protects Mice from Viral Pathogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.