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Article

Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2004

Yamanaka Atsushi, Hamano Shinjiro, Miyazaki Yoshiyuki, Ishii Kazunari, Takeda Atsunobu, Mak Tak W, Himeno Kunisuke, Yoshimura Akihiko, Yoshida Hiroki

Abstract excerpt

Administration of Con A induces liver injury that is considered to be an experimental model for human autoimmune or viral hepatitis, where immunopathology plays roles mediated by activated lymphocytes, especially NK1.1+ CD3+ NKT cells, and inflammatory cytokines, including IFN-gamma and IL-4. In the present study we investigated the role of WSX-1, a component of IL-27R, in Con A-induced hepatitis by taking...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15004160
DOI: 10.4049/jimmunol.172.6.3590

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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