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Article

Nitric oxide contributes to the development of a post-injury Th2 T-cell phenotype and immune dysfunction.

Journal of cellular physiology - 1 Aug 2006

Daniel Tanjanika, Alexander Michelle, Hubbard William J, Chaudry Irshad H, Choudhry Mashkoor A, Schwacha Martin G

Abstract excerpt

Severe injury induces immune dysfunction resulting in increased susceptibility to opportunistic infections. Previous studies from our laboratory have demonstrated that post-burn immunosuppression is mediated by nitric oxide (NO) due to the increased expression of macrophage inducible nitric oxide synthase (iNOS). In contrast, others suggest that injury causes a phenotypic imbalance in the regulation of Th1- and...

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Identifiers

PMID: 16642464
DOI: 10.1002/jcp.20677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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