Article
A complete genetic association scan of the 22q11 deletion region and functional evidence reveal an association between DGCR2 and schizophrenia.
Human genetics - 1 Sept 2006
Shifman Sagiv, Levit Anat, Chen Mao-Liang, Chen Chia-Hsiang, Bronstein Michal, Weizman Avraham, Yakir Benjamin, Navon Ruth, Darvasi Ariel
Abstract excerpt
Several lines of evidence have established the presence of an association between a 3-Mb deletion in chromosome 22q11 and schizophrenia. In this paper we present a complete high-density SNP scan of this segment using DNA pools, and demonstrate significant association between two distinct regions and schizophrenia in an Ashkenazi Jewish population. One of these regions contains the previously identified COMT gene....
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