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Article

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.

Journal of medicinal chemistry - 18 Nov 2004

Hopkins Andrew L, Ren Jingshan, Milton John, Hazen Richard J, Chan Joseph H, Stuart David I, Stammers David K

Abstract excerpt

We have used a structure-based approach to design a novel series of non-nucleoside inhibitors of HIV-1 RT (NNRTIs). Detailed analysis of a wide range of crystal structures of HIV-1 RT-NNRTI complexes together with data on drug resistance mutations has identified factors important for tight bindin...

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Source

Identifiers

PMID: 15537346
DOI: 10.1021/jm040071z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15537346-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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