Article
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.
Bioorganic & medicinal chemistry letters - 1 Apr 2007
Barreca Maria Letizia, Rao Angela, De Luca Laura, Iraci Nunzio, Monforte Anna-Maria, Maga Giovanni, De Clercq Erik, Pannecouque Christophe, Balzarini Jan, Chimirri Alba
Abstract excerpt
Molecular modeling studies led to the rational discovery of N(1)-arylsulfonyl-1,3-dihydro-2H-benzimidazol-2-one as a novel template for the design of new non-nucleoside reverse transcriptase inhibitors (NNRTIs) that are active against wild-type and mutant strains of HIV-1. It is worth noting that compound 3 proved to have antiretroviral activity similar to that of efavirenz and greater than that of nevirapine,...
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