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Article

Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans.

The Journal of biological chemistry - 6 Jan 2006

Kuwahara Tomoki, Koyama Akihiko, Gengyo-Ando Keiko, Masuda Mayumi, Kowa Hisatomo, Tsunoda Makoto, Mitani Shohei, Iwatsubo Takeshi

Abstract excerpt

Mutations in alpha-synuclein gene cause familial form of Parkinson disease, and deposition of wild-type alpha-synuclein as Lewy bodies occurs as a hallmark lesion of sporadic Parkinson disease and dementia with Lewy bodies, implicating alpha-synuclein in the pathogenesis of Parkinson disease and related neurodegenerative diseases. Dopamine neurons in substantia nigra are the major site of neurodegeneration...

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PMID: 16260788
DOI: 10.1074/jbc.M504860200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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