Article
Radiation clastogenesis and cell cycle checkpoint function as functional markers of breast cancer risk.
Carcinogenesis - 1 Dec 2006
Kaufmann William K, Filatov Leonid, Oglesbee Stephen E, Simpson Dennis A, Lotano Marc A, McKeen Hayley D, Sawyer Lynda R, Moore Dominic T, Millikan Robert C, Cordeiro-Stone Marila, Carey Lisa A
Abstract excerpt
BACKGROUND: Familial breast cancer is associated with mutations in several genes (BRCA1, BRCA2, p53, ATM) whose protein products protect against radiation-induced genotoxicity. This study tested whether sporadic breast cancer was associated with constitutive radiation hypersensitivity. METHODS: Blood lymphocytes and EBV-transformed lymphoblasts from patients with newly diagnosed breast cancer and controls without...
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