Article
Chromosomal radiosensitivity of breast cancer with a CHEK2 mutation.
Cancer genetics and cytogenetics - 1 Dec 2005
Baeyens Ans, Claes Kathleen, Willems Petra, De Ruyck Kim, Thierens Hubert, Vral Anne
Abstract excerpt
Recently, multiple studies have shown that a sequence variant in CHEK2 (CHEK2 1100delC) plays a role in the susceptibility to breast cancer. This mutation should confer about a twofold increased breast cancer risk in women and a 10-fold increased risk in men. Because the CHEK2 gene plays a critical role in DNA damage repair and the CHEK2 1100delC variant confers susceptibility to breast cancer, we investigated if...
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