Article
Coexistence of angiotensin II type-1 receptor A1166C and angiotensin-converting enzyme D/D polymorphism suggests susceptibility for small-vessel-associated ischemic stroke.
Neuromolecular medicine - 1 Jan 2006
Szolnoki Zoltán, Maasz Anita, Magyari Lili, Horvatovich Katalin, Farago Bernadett, Somogyvari Ferenc, Kondacs Andras, Szabo Mihaly, Fodor Lajos, Bodor Anita, Hadarits Ferenc, Melegh Bela
Abstract excerpt
The renin-angiotensin system plays an important role in the maintenance of blood pressure homeostasis. The angiotensin-converting enzyme (ACE) converts angiotensin I into angiotensin II. Angiotensin II, which binds the angiotensin II type-1 receptor (AT1R), is a potent vasoconstrictor. On a pathophysiological basis, both ACE I/D and AT1R A1166C polymorphism lead to an enhanced activity of the angiotensin II-AT1R...
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