Article
Possible synergic effect of angiotensin-I converting enzyme gene insertion/deletion polymorphism and angiotensin-II type-1 receptor 1166A/C gene polymorphism on ischemic heart disease in patients with Kawasaki disease.
Pediatric research - 1 Oct 2004
Fukazawa Ryuji, Sonobe Tomoyoshi, Hamamoto Kunihiro, Hamaoka Kenji, Sakata Koichi, Asano Takeshi, Imai Takehide, Kamisago Mitsuhiro, Ohkubo Takashi, Uchikoba Yohko, Ikegami Ei, Watanabe Miki, Ogawa Shunichi
Abstract excerpt
ACE I/D and AT1R 1166A/C polymorphisms are considered to comprise individual risk factors for the development of coronary disease. We sought to demonstrate that the ACE I/D and AT1R 1166A/C polymorphisms affect coronary artery stenosis in patients with Kawasaki disease (KD). We examined 147 healthy controls and 281 Japanese children with KD. The patients were further divided into group N (n = 246, no ischemia)...
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