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Article

Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population.

Molecular diagnosis & therapy - 1 Jan 2006

Bosch T M, Doodeman V D, Smits P H M, Meijerman I, Schellens J H M, Beijnen J H

Abstract excerpt

BACKGROUND: A possible explanation for the wide interindividual variability in toxicity and efficacy of drug therapy is variation in genes encoding drug-metabolizing enzymes and drug transporters. The allelic frequency of these genetic variants, linkage disequilibrium (LD), and haplotype of these polymorphisms are important parameters in determining the genetic differences between patients. The aim of this study...

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Source

Identifiers

PMID: 16771603
DOI: 10.1007/BF03256456

Genes

ABCC2
ABCB1
DPYD
GSTM1
GSTP1
GSTT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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