Article
Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy.
Platelets - 1 Jun 2006
Smith Simon M G, Judge Heather M, Peters Gary, Armstrong Martin, Fontana Pierre, Gaussem Pascale, Daly Martina E, Storey Robert F
Abstract excerpt
The efficacy of the platelet P2Y12 receptor antagonist clopidogrel, which undergoes cytochrome-mediated metabolism to its active form, shows marked inter-individual variability. We investigated whether polymorphic variations in the P2Y12 gene, which have been linked to platelet aggregation phenotypes, or the cytochrome P450 3A5 gene 6986G > A polymorphism, which largely determines CYP3A5 expression, influence the...
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