Article
Role of the T744C polymorphism of the P2Y12 gene on platelet response to a 600-mg loading dose of clopidogrel in 597 patients with non-ST-segment elevation acute coronary syndrome.
Thrombosis research - 1 Jan 2007
Cuisset Thomas, Frere Corinne, Quilici Jacques, Morange Pierre-Emmanuel, Saut Noémie, Lambert Marc, Camoin Laurence, Vague Irène Juhan, Bonnet Jean-Louis, Alessi Marie-Christine
Abstract excerpt
BACKGROUND: Variability in platelet response to clopidogrel and its clinical relevance have been well described. However, the underlying mechanisms remain unclear. Recently, the T744C polymorphism of the P2Y12 receptor gene has been associated with enhanced platelet aggregation in healthy volunte...
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