Article
Potential clinical utility of genetic and platelet function tests in patients on treatment with clopidogrel.
Journal of cardiovascular medicine (Hagerstown, Md.) - 1 Dec 2013
Cattaneo Marco
Abstract excerpt
Clopidogrel, a pro-drug whose active metabolite is an inhibitor of the platelet P2Y12 receptor, is used mostly for the prevention of cardiovascular events in patients with acute coronary syndromes undergoing percutaneous coronary interventions. However, clopidogrel is associated with great variability in antiplatelet response, mostly caused by variable efficacy of cytochrome P450 (CYP) isoforms, which convert...
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