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Article

Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne - 6 Jun 2006

Suh Jung-Won, Koo Bon-Kwon, Zhang Shu-Ying, Park Kyung-Woo, Cho Joo-Youn, Jang In-Jin, Lee Dong-Soon, Sohn Dae-Won, Lee Myoung-Mook, Kim Hyo-Soo

Abstract excerpt

BACKGROUND: Clopidogrel is a prodrug requiring metabolism by cytochrome P450 3A (CYP3A) isoenzymes, including CYP3A5, in order to be active. It is controversial whether clopidogrel interacts with CYP3A inhibitors. We investigated the influence of CYP3A5 polymorphism on the drug interaction of clopidogrel. METHODS: In phase 1 of the study, we administered clopidogrel to 16 healthy volunteers who had the CYP3A5...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16754899
DOI: 10.1503/cmaj.060664
PMCID: PMC1471813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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