A single nucleotide substitution in the D domain of estrogen receptor cDNA causes amino acid alteration from Glu-279 to Lys-279 in a murine transformed Leydig cell line (B-1 F).

doi:10.1016/0960-0760(91)90004-o

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A single nucleotide substitution in the D domain of estrogen receptor cDNA causes amino acid alteration from Glu-279 to Lys-279 in a murine transformed Leydig cell line (B-1 F).

The Journal of steroid biochemistry and molecular biology - 1 Jul 1991

Hirose T, Koga M, Matsumoto K, Sato B

Abstract excerpt

A polymerase chain reaction method was carried out to address the possible presence of estrogen receptor (ER) mutations in murine transformed cell lines. The segment of ER cDNA coding the C and D domains was amplified and cloned into pUC 19. Mammary carcinoma cell line (SC-3) did not show any mutation in this segment. However, the sequence analysis of ER in the Leydig cell line (B-1 F) revealed a single base...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Line, Transformed
Chickens
Glutamates
Glutamic Acid
Humans
Leydig Cells
Lysine
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mammary Neoplasms, Experimental

Mice

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

RNA, Messenger

Rats

Source

Open in PubMed

Identifiers

PMID: 1676903
DOI: 10.1016/0960-0760(91)90004-o

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1676903-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

A single nucleotide substitution in the D domain of estrogen receptor cDNA causes amino acid alteration from Glu-279 to Lys-279 in a murine transformed Leydig cell line (B-1 F).PMID 1676903Read ↗

Aromatase and breast cancer: W39R, an inactive protein.Semantic proximity Read ↗

The N-terminal transactivation domain of rat estrogen receptor is localized in a hydrophobic domain of eighty amino acids.Semantic proximity Read ↗

Estrogen receptor mutations.Semantic proximity Read ↗

Estrogen receptor variants and mutations.Semantic proximity Read ↗

Estrogen receptor mutations in human disease.Semantic proximity Read ↗

Human Cancers Deriving from Either Genetic or Lifestyle Factors, Are Initiated by the Damage of Estrogen SignalingSemantic proximity Read ↗

A Closer Look at Estrogen Receptor Mutations in Breast Cancer and Their Implications for Estrogen and Antiestrogen Responses.Semantic proximity Read ↗

Genetic and epigenetic alterations of the estrogen receptor gene and hormone independence in human breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.