Article
Aromatase and breast cancer: W39R, an inactive protein.
European journal of endocrinology - 1 Apr 2002
Nativelle-Serpentini C, Lambard S, Séralini G E, Sourdaine P
Abstract excerpt
BACKGROUND: Aromatase (CYP19) catalyzes the conversion of androgens into estrogens. It is in particular involved in development, reproduction and breast cancer. One of its polymorphisms, W39R localized in the N-terminal region of CYP19, significantly decreases breast cancer risk among Japanese women and was chosen for this study. In this work, we studied the structure-function relationships between W39R...
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