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Article

[Hepatocyte-specific Pten deficient mice].

Nihon rinsho. Japanese journal of clinical medicine - 1 Jun 2006

Horie Yasuo, Ohshima Shigetoshi, Sato Wataru, Suzuki Akira, Watanabe Sumio

Abstract excerpt

Histological findings of hepatocyte-specific Pten deficient(Pten KO) mice livers were consistent with the criteria of human nonalcoholic steatohepatitis(NASH). Therefore, Pten KO mice are a powerful animal model of NASH. In Pten KO mice livers, steatosis develops based on the increased expression of genes that promote fatty acids synthesis. The increased expression of beta, oxidation-related genes accumulates...

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PMID: 16768106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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