Article
[The role of Fas mutation on non-alcoholic steatohepatitis in mice].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology - 1 Sept 2011
Su Shan-shan, Han Fang, Wang Rong-qi, Ren Wei-guang, Wu Wen-juan, Kong Ling-bo, Zhao Su-xian, Nan Yue-min
Abstract excerpt
OBJECTIVE: Our previous study indicated that the death receptor Fas played a key role on hepatocyte apoptosis in nutritional steatohepatitis in mice. This study aimed to explore whether Fas mutation accelerated hepatic steatosis and inflammatory infiltration in methionine-choline deficient (MCD) diet feeding mice. METHODS: Mice homozygous for the lymphoproliferation spontaneous mutation (C57BL/6J-Faslpr) and wild...
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