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Article

Tuberculosis in children and adults: two distinct genetic diseases.

The Journal of experimental medicine - 19 Dec 2005

Alcaïs Alexandre, Fieschi Claire, Abel Laurent, Casanova Jean-Laurent

Abstract excerpt

Disseminated disease in children and pulmonary disease in adults constitute two major epidemiological and clinical forms of tuberculosis. Paradoxically, only a small fraction of infected individuals develop clinical tuberculosis, typically one form of the disease or the other. Mendelian and complex genetic predispositions to tuberculosis were reported recently in children and adults, respectively. Here, we argue...

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Identifiers

PMID: 16365144
DOI: 10.1084/jem.20052302
PMCID: PMC2212964

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