Article
Intact T cell responses in ataxia telangiectasia.
Clinical immunology (Orlando, Fla.) - 1 Aug 2006
Pashankar Farzana, Singhal Vibha, Akabogu Ike, Gatti Richard A, Goldman Frederick D
Abstract excerpt
Ataxia telangiectasia (A-T) is an autosomal recessive multisystem disorder associated with a variable immune deficiency. The mechanism for this remains unclear. Qualitative and quantitative defects of cellular immunity have been previously reported. However, despite laboratory evidence of significant immune abnormalities, opportunistic infections are uncommon. To address this discrepancy, we analyzed cytokine...
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