Article
Parents of ataxia-telangiectasia patients display a distinct cellular immune phenotype mimicking ATM-mutated patients.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Feb 2021
Ogulur Ismail, Ertuzun Tugce, Kocamis Burcu, Kendir Demirkol Yasemin, Uyar Emel, Kiykim Ayca, Baser Dilek, Yesil Gozde, Akturk Hacer, Somer Ayper, Ozen Ahmet, Karakoc-Aydiner Elif, Muftuoglu Meltem, Baris Safa
Abstract excerpt
BACKGROUND: Heterozygous relatives of ataxia-telangiectasia (AT) patients are at an increased risk for certain AT-related manifestations. We also show that there is an increase of infection frequency in parents of AT patients. Thus, we hypothesized that the parents might exhibit immune alterations similar to their affected children. METHODS: Lymphocyte phenotyping to enumerate T- and B-cell subsets was performed....
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