Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Skewed T-cell receptor repertoire, decreased thymic output, and predominance of terminally differentiated T cells in ataxia telangiectasia

14 Nov 2002

Abstract excerpt

Ataxia telangiectasia (A-T), a genetic disorder caused by the homozygous mutation of the ATM gene, frequently associates with variable degrees of cellular and humoral immunodeficiency. However, the immune defects occurring in patients with A-T are still poorly characterized. Here we show that the T-cell receptor (TCR) variable beta (BV)-chain repertoire of 9 A-T patients was restricted by diffuse expansions of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to DNA Repair Mechanisms
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12393664
DOI: 10.1182/blood-2002-03-0976

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Skewed T-cell receptor repertoire, decreased thymic output, and predominance of terminally differentiated T cells in ataxia telangiectasiaPMID 12393664Read ↗

Disturbed B and T cell homeostasis and neogenesis in patients with ataxia telangiectasia.Semantic proximity Read ↗

Variable Abnormalities in T and B Cell Subsets in Ataxia Telangiectasia.Semantic proximity Read ↗

Unusual clinical manifestations and predominant stopgain ATM gene variants in a single centre cohort of ataxia telangiectasia from North India.Semantic proximity Read ↗

Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversitySemantic proximity Read ↗

Progressive Depletion of B and T Lymphocytes in Patients with Ataxia Telangiectasia: Results of the Italian Primary Immunodeficiency Network.Semantic proximity Read ↗

Causative mechanisms and clinical impact of immunoglobulin deficiencies in ataxia telangiectasiaSemantic proximity Read ↗

T-cell receptor beta chain variability in bone marrow and peripheral blood in severe acquired aplastic anemia.Semantic proximity Read ↗

Poor-Quality Vβ Recombination Signal Sequences and the DNA Damage Response ATM Kinase Collaborate to Establish TCRβ Gene Repertoire and Allelic Exclusion.Semantic proximity Read ↗

ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytesSemantic proximity Read ↗

Parents of ataxia-telangiectasia patients display a distinct cellular immune phenotype mimicking ATM-mutated patients.Semantic proximity Read ↗

ATM Expression and Activation in Ataxia Telangiectasia Patients with and without Class Switch Recombination Defects.Semantic proximity Read ↗

Unexpected and variable phenotypes in a family with JAK3 deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.