Article
Disturbed B and T cell homeostasis and neogenesis in patients with ataxia telangiectasia.
Journal of clinical immunology - 1 Jul 2014
Kraus Matan, Lev Atar, Simon Amos J, Levran Inbal, Nissenkorn Andrea, Levi Yonit B, Berkun Yackov, Efrati Ori, Amariglio Ninette, Rechavi Gideon, Somech Raz
Abstract excerpt
OBJECTIVE: Ataxia telangiectasia (AT) is a rare genetic, multi-system disorder characterized by neurodegeneration, chromosome instability, B and T cell immunodeficiency and a predisposition to cancer. We examined immunologic parameters reflecting cell development and proliferation and their relevancy to the clinical phenotype in affected individuals. PATIENTS AND METHODS: AT patients from the AT National Clinic...
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