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Article

CYP3A phenotypes and genotypes in North Indians.

European journal of clinical pharmacology - 1 Jun 2006

Rais Naushad, Chawla Yogesh K, Kohli Krishan K

Abstract excerpt

OBJECTIVES: To phenotype 200 healthy North Indians for cytochrome P450 3A (CYP3A) activity by measuring urinary ratio of 6beta-OH-cortisol/cortisol (6beta-OH-CS/CS) and to genotype the subjects demonstrating low and high CYP3A activity for the presence of CYP3A4*1B, *2, *4, *5, *6 and *10 alleles. METHODS: Morning spot urine samples were collected from 200 healthy North Indians. CS and 6beta-OH-CS were extracted...

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PMID: 16758258
DOI: 10.1007/s00228-006-0105-3

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