Article
Within-person variability of urinary 6beta-hydroxycortisol to urinaryl ratios in Caucasian women.
Steroids - 1 Jan 2004
Chen Zhi, Dunning Lisa A, Anderson Kristin E, Holtzman Jordan L, Zheng Wei
Abstract excerpt
Cortisol is metabolized to 6beta-hydroxycortisol by human cytochrome p450-3A4 (CYP3A4), an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds. Both cortisol and 6beta-hydroxycortisol are excreted in urine, and the ratio of these steroids has been proposed as an indicator of CYP3A4 activity. We evaluated within-person variability of this biomarker in 10 healthy Caucasian...
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