Article
Genotype-phenotype variability in human CYP3A locus in Nepalese people residing in Bangladesh.
International journal of clinical pharmacology and therapeutics - 1 Mar 2013
Hassan Rajib, Ameen Syeda Sadia, Al Maruf Abdullah, Nandini Ananna, Tabin Humayra, Ahmed Maizbha Uddin, Islam Mohammad Safiqul, Bin Sayeed Muhammad Shahdaat, Hasnat Abul
Abstract excerpt
OBJECTIVES: The study has been designed to phenotype 200 Nepalese people residing in Bangladesh by measuring urinary ratio of 6β-hydroxycortisol/cortisol (metabolic ratio) and to genotype all the subjects for the presence of CYP3A4*1B, *2, *4, *5, *6, *10, *18, CYP3A5*3, and *6 alleles. METHODS: Cortisol and 6β-hydroxycortisol were extracted and quantified from morning spot urine samples (n = 200) by HPLC....
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