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Article

Molecular basis of opsonic defect in immunodeficient children.

Lancet (London, England) - 29 Jun 1991

Sumiya M, Super M, Tabona P, Levinsky R J, Arai T, Turner M W, Summerfield J A

Abstract excerpt

Low serum mannose-binding protein (MBP) concentrations are associated with a common opsonic defect. Sequence analysis of the MBP gene in three children with recurrent infections, the opsonic defect, and low serum MBP concentrations showed a point mutation at base 230 of exon 1 causing a change of...

Topics

Alleles
Carrier Proteins
DNA
Exons
Genotype
Humans
Immunologic Deficiency Syndromes
Infant, Newborn
Mannose-Binding Lectins
Molecular Sequence Data
Mutation
Nucleic Acid Probes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Opsonin Proteins

Pedigree

Source

Identifiers

PMID: 1675710
DOI: 10.1016/0140-6736(91)93263-9

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1675710-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Molecular basis of opsonic defect in immunodeficient children.PMID 1675710Read ↗

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