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Article

Molecular basis of opsonic defect in immunodeficient children.

Lancet (London, England) - 29 Jun 1991

Sumiya M, Super M, Tabona P, Levinsky R J, Arai T, Turner M W, Summerfield J A

Abstract excerpt

Low serum mannose-binding protein (MBP) concentrations are associated with a common opsonic defect. Sequence analysis of the MBP gene in three children with recurrent infections, the opsonic defect, and low serum MBP concentrations showed a point mutation at base 230 of exon 1 causing a change of codon 54 from GGC to GAC. The replacement of glycine with an aspartic acid residue disrupts the fifth Gly-Xaa-Yaa...

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Identifiers

PMID: 1675710
DOI: 10.1016/0140-6736(91)93263-9

Genes

MBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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