Mannose binding protein gene mutations associated with unusual and severe infections in adults.

doi:10.1016/s0140-6736(95)90009-8

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Article

Mannose binding protein gene mutations associated with unusual and severe infections in adults.

Lancet (London, England) - 8 Apr 1995

Summerfield J A, Ryder S, Sumiya M, Thursz M, Gorchein A, Monteil M A, Turner M W

Abstract excerpt

A defect in opsonisation can cause a common immunodeficiency. A mutation in mannose binding protein (MBP) caused by point mutations in the MBP gene will lead to such a defect. This type of syndrome can cause recurrent infections in infants between 6 and 18 months of age but is not generally belie...

Topics

Adolescent
Adult
Carrier Proteins
Codon
Female
Humans
Infections
Male
Mannose-Binding Lectins
Middle Aged
Mutation
Pedigree

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