Article
HOXA5 regulates hMLH1 expression in breast cancer cells.
Neoplasia (New York, N.Y.) - 1 Apr 2006
Duriseti Sai, Winnard Paul T, Mironchik Yelena, Vesuna Farhad, Raman Ana, Raman Venu
Abstract excerpt
Homeobox protein HOXA5 functions as a transcriptional factor for genes that are not only involved in segmentation identity but also in cell differentiation. Although HOXA5 has been shown to regulate the expression of the tumor-suppressor protein p53, its role in breast tumorigenesis is not well understood. Using yeast as a model system, we now demonstrate that overexpression of HOXA5 in yeast can be used to...
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