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Article

Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jun 2006

Tuo Jingsheng, Ning Baitang, Bojanowski Christine M, Lin Zhong-Ning, Ross Robert J, Reed George F, Shen Defen, Jiao Xiaodong, Zhou Min, Chew Emily Y, Kadlubar Fred F, Chan Chi-Chao

Abstract excerpt

This study investigates age-related macular degeneration (AMD) genetic risk factors through identification of a functional single-nucleotide polymorphism (SNP) and its disease association. We chose ERCC6 because of its roles in the aging process, DNA repair, and ocular degeneration from the gene disruption. Bioinformatics indicated a putative binding-element alteration on the sequence containing C-6530>G SNP in...

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Share to 5' Flanking Region
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16754848
DOI: 10.1073/pnas.0603485103
PMCID: PMC1474016

Genes

ERCC6
CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition.PMID 16754848Read ↗

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