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Article

Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.

The Journal of biological chemistry - 4 Aug 2006

Ang Hwee Ching, Joerger Andreas C, Mayer Sebastian, Fersht Alan R

Abstract excerpt

Common cancer mutations of p53 tend either to lower the stability or distort the core domain of the protein or weaken its DNA binding affinity. We have previously analyzed in vitro the effects of mutations on the core domain of p53. Here, we extend those measurements to full-length p53, using either the wild-type protein or a biologically active superstable construct that is more amenable to accurate biophysical...

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PMID: 16754663
DOI: 10.1074/jbc.M604209200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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