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Article

Why is mammalian thioredoxin reductase 1 so dependent upon the use of selenium?

Biochemistry - 28 Jan 2014

Lothrop Adam P, Snider Gregg W, Ruggles Erik L, Hondal Robert J

Abstract excerpt

Cytosolic thioredoxin reductase 1 (TR1) is the best characterized of the class of high-molecular weight (Mr) thioredoxin reductases (TRs). TR1 is highly dependent upon the rare amino acid selenocysteine (Sec) for the reduction of thioredoxin (Trx) and a host of small molecule substrates, as mutation of Sec to cysteine (Cys) results in a large decrease in catalytic activity for all substrate types. Previous work...

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Identifiers

PMID: 24393022
DOI: 10.1021/bi400651x
PMCID: PMC3957196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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