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Article

Single amino acid residue determinants of non-peptide antagonist binding to the corticotropin-releasing factor1 (CRF1) receptor.

Biochemical pharmacology - 14 Jul 2006

Hoare Sam R J, Brown Brock T, Santos Mark A, Malany Siobhan, Betz Stephen F, Grigoriadis Dimitri E

Abstract excerpt

The molecular interactions between non-peptide antagonists and the corticotropin-releasing factor type 1 (CRF1) receptor are poorly understood. A CRF1 receptor mutation has been identified that reduces binding affinity of the non-peptide antagonist NBI 27914 (M276I in transmembrane domain 5). We...

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Identifiers

PMID: 16750175
DOI: 10.1016/j.bcp.2006.04.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16750175-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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