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Article

Use of targetrons to disrupt essential and nonessential genes in <i>Staphylococcus aureus</i> reveals temperature sensitivity of Ll.LtrB group II intron splicing

1 Jun 2006

Abstract excerpt

We show that a targetron based on the Lactococcus lactis Ll.LtrB group II intron can be used for efficient chromosomal gene disruption in the human pathogen Staphylococcus aureus. Targetrons expressed from derivatives of vector pCN37, which uses a cadmium-inducible promoter, or pCN39, a derivative of pCN37 with a temperature-sensitive replicon, gave site-specific disruptants of the hsa and seb genes in 37%-100%...

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PMID: 16741231
DOI: 10.1261/rna.68706

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