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The Transcriptional Program of Staphylococcus aureus Phage K Is Affected by a Host rpoC Mutation That Confers Phage K Resistance.

Viruses - 13 Nov 2024

Kongari Rohit, Ray Melissa D, Lehman Susan M, Plaut Roger D, Hinton Deborah M, Stibitz Scott

Abstract excerpt

To better understand host-phage interactions and the genetic bases of phage resistance in a model system relevant to potential phage therapy, we isolated several spontaneous mutants of the USA300 S. aureus clinical isolate NRS384 that were resistant to phage K. Six of these had a single missense mutation in the host rpoC gene, which encodes the RNA polymerase β' subunit. To examine the hypothesis that mutations...

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Share to Antimicrobial Resistance in Staphylococcus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39599887
DOI: 10.3390/v16111773
PMCID: PMC11598898

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