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Article

Molecular Interaction of BMP-4, TGF-β, and Estrogens in Lactotrophs: Impact on the PRL Promoter

2 Apr 2009

Abstract excerpt

The regulatory role of estrogen, bone morphogenetic protein-4 (BMP-4), and TGF-beta has a strong impact on hormone secretion, gene transcription, and cellular growth of prolactin (PRL)-producing cells. In contrast to TGF-beta, BMP-4 induces the secretion of PRL in GH3 cells. Therefore, we studied the mechanism of their transcriptional regulation. Both BMP-4 and TGF-beta inhibited the transcriptional activity of...

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PMID: 19342445
DOI: 10.1210/me.2008-0425

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